The identification of disease specific genes is pivotal in clinical informatics. This paper describes an improved algorithm for machine learning in which the negative N is classified more appropriately as Unknown U.

English: Weka Data Mining Open Software in Java (Photo credit: Wikipedia)

Peng Yang, Xiao-Li Li, Jian-Ping Mei, Chee-Keong Kwoh, and See-Kiong Ng. Positive-Unlabeled Learning for Disease Gene Identification
Bioinformatics first published online August 24, 2012 doi:10.1093/bioinformatics/bts504

SVMs are an important tool in bioinformaticians armamentarium. Weka is a collection of machine learning algorithms for data mining tasks.