Psoriasis is essentially a proliferative disorder like Lamellar ichthyosis mentioned below. One of the most effective drugs in psoriasis is methotrexate (MTX). Though traditionally we see MTX as an antifolate drug, this does not fully explain its anti psoriatic effect. Various genetic polymorphisms and its effect on MTX cellular pharmacology are described. Can the Bioinformatics study of MTX polymorphisms and its effect on cell division in relation to mutations in Lamellar Ichthyosis (Which are very well characterized unlike Psoriasis) be useful? Post your thoughts here and contact me http://www.gulfdoctor.net/research.htm if you interested in exploring this together.